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Lower limb linear morphoea in a pregnant woman with known G raves' disease and cytomegalovirus immunoglobulin M positivity
Author(s) -
Wong Brittany,
Piliouras Peter,
Mortimore Rohan,
Zonta Mark,
Tucker Simon
Publication year - 2015
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12173
Subject(s) - medicine , dermis , histopathology , pathology , pregnancy , connective tissue disease , cytomegalovirus , fibrosis , thigh , anatomy , autoimmune disease , disease , herpesviridae , virus , viral disease , immunology , biology , genetics
We report a case of linear morphoea in a 21‐year‐old woman with known G raves' disease who was also cytomegalovirus ( CMV) IgM ‐positive and in her early first trimester of pregnancy. The histopathology showed hyalinisation of the dermis with perivascular superficial and deep lymphocytic infiltrates extending into the septae of the subcutis and impinging on adjacent lobules; there was also fibrosis of the subcutis. Magnetic resonance imaging showed T2 high intensity of the subcutaneous tissue and intermuscular planes of the thigh and leg. It is well known that morphoea can follow pregnancy and thyroid disease and that CMV is postulated to contribute in some patients. This case highlights a combination of risk factors for this disease that have not been reported collectively in the literature to our knowledge.