Premium
Retrospective follow up of gross motor development in children using propranolol for treatment of infantile haemangioma at S ydney Children's Hospital
Author(s) -
Gonski Kate,
Wargon Orli
Publication year - 2014
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12156
Subject(s) - medicine , propranolol , retrospective cohort study , gross motor skill , pediatrics , vincristine , gestational age , adverse effect , anesthesia , surgery , chemotherapy , motor skill , pregnancy , psychiatry , biology , cyclophosphamide , genetics
Questions have been raised as to whether propranolol, which crosses the blood‐brain barrier, when used early in life may have an adverse effect on gross motor development. A retrospective survey asking questions about gross motor development was sent to the families of children who had been prescribed oral propranolol for infantile haemangioma at S ydney Children's Hospital between 2008 and 2013. It was found that of the 84 patients surveyed, four were delayed in walking unassisted. There was a statistically significant influence if the child was taking other medications which included prednisolone, vincristine, omeprazole, ranitidine, salbutamol, Flixotide, Timoptol and antibiotics. This was not further analysed in this study because of the low numbers involved. There was no statistically significant influence of gestational age, birth weight or length of time on propranolol. This study adds to the retrospective data available; however large‐scale prospective studies are needed to identify unexpected long‐term side‐effects.