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Acute cutaneous graft‐versus‐host disease resembling type II (atypical adult) pityriasis rubra pilaris
Author(s) -
Surjana Devita,
Robertson Ivan,
Kennedy Glen,
James Daniel,
Weedon David
Publication year - 2015
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12108
Subject(s) - pityriasis rubra pilaris , medicine , tacrolimus , graft versus host disease , dermatology , etanercept , methylprednisolone , ichthyosis , palmoplantar keratoderma , hyperkeratosis , pathology , transplantation , immunology , disease , tumor necrosis factor alpha , psoriasis
We present a case of cutaneous acute graft‐versus‐host disease ( aGVHD ) with confluent erythematous perifollicular hyperkeratosis and ichthyosiform scale in the clinical pattern of type II (atypical adult) pityriasis rubra pilaris ( PRP ), which developed 26 days after allogeneic peripheral blood stem cell transplant. Skin histology confirmed features of both aGVHD and PRP . The skin lesions were refractory to oral prednisolone and cyclosporine and only partially responsive to a combination of i.v. methylprednisolone, oral tacrolimus, oral mycophenolate mofetil, and infusions of anti‐thymocyte globulin and the tumour necrosis factor‐α inhibitor, etanercept.