Acute cutaneous graft‐versus‐host disease resembling type  II  (atypical adult) pityriasis rubra pilaris | Zendy

Surjana Devita | Zendy; Robertson Ivan | Zendy; Kennedy Glen | Zendy; James Daniel | Zendy; Weedon David | Zendy

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Acute cutaneous graft‐versus‐host disease resembling type II (atypical adult) pityriasis rubra pilaris

Author(s) -

Surjana Devita,

Robertson Ivan,

Kennedy Glen,

James Daniel,

Weedon David

Publication year - 2015

Publication title -

australasian journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.67

H-Index - 53

eISSN - 1440-0960

pISSN - 0004-8380

DOI - 10.1111/ajd.12108

Subject(s) - pityriasis rubra pilaris , medicine , tacrolimus , graft versus host disease , dermatology , etanercept , methylprednisolone , ichthyosis , palmoplantar keratoderma , hyperkeratosis , pathology , transplantation , immunology , disease , tumor necrosis factor alpha , psoriasis

We present a case of cutaneous acute graft‐versus‐host disease ( aGVHD ) with confluent erythematous perifollicular hyperkeratosis and ichthyosiform scale in the clinical pattern of type II (atypical adult) pityriasis rubra pilaris ( PRP ), which developed 26 days after allogeneic peripheral blood stem cell transplant. Skin histology confirmed features of both aGVHD and PRP . The skin lesions were refractory to oral prednisolone and cyclosporine and only partially responsive to a combination of i.v. methylprednisolone, oral tacrolimus, oral mycophenolate mofetil, and infusions of anti‐thymocyte globulin and the tumour necrosis factor‐α inhibitor, etanercept.

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