CD25 + folliculotropic  S ézary syndrome with  CD30 + large cell transformation | Zendy

Jang Min Soo | Zendy; Kang Dong Young | Zendy; Han Sang Hwa | Zendy; Park Jong Bin | Zendy; Kim Sang Tae | Zendy; Suh Kee Suck | Zendy

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CD25 + folliculotropic S ézary syndrome with CD30 + large cell transformation

Author(s) -

Jang Min Soo,

Kang Dong Young,

Han Sang Hwa,

Park Jong Bin,

Kim Sang Tae,

Suh Kee Suck

Publication year - 2014

Publication title -

australasian journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.67

H-Index - 53

eISSN - 1440-0960

pISSN - 0004-8380

DOI - 10.1111/ajd.12000

Subject(s) - mycosis fungoides , medicine , cd30 , lymphoma , cutaneous lymphoma , cutaneous t cell lymphoma , dermatology , aggressive lymphoma , pathology , rituximab

Folliculotropic S ézary syndrome is a rare and unique variant of cutaneous T ‐cell lymphoma ( CTCL ) characterised by both follicular and leukaemic involvement of mycosis fungoides ( MF ). It is associated with a more aggressive clinical course and fatal outcomes. Large cell transformation ( LCT ) of mycosis fungoides/ S ézary syndrome is also associated with an aggressive disease course and shortened survival, requiring an intensive therapeutic approach. This report describes a case of folliculotropic S ézary syndrome with CD30 + LCT . Most of the larger lymphocytes in the lesions were positive for CD25 , the expression of which is associated with advanced CTCL . In addition, we review the literature on this unusual CTCL and provide evidence that this entity represents a distinct clinicopathological entity occasionally associated with extracutaneous involvement and LCT .

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