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Age‐based efficacy and safety of nivolumab for recurrent or metastatic head and neck squamous cell carcinoma: A multicenter retrospective study
Author(s) -
Kondo Takahito,
Okamoto Isaku,
Sato Hiroki,
Koyama Nobuyuki,
Fushimi Chihiro,
Okada Takuro,
Masubuchi Tatsuo,
Miura Kouki,
Matsuki Takashi,
Yamashita Taku,
Omura Go,
Takahashi Hideaki,
Tsukahara Kiyoaki
Publication year - 2020
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.13374
Subject(s) - medicine , nivolumab , adverse effect , head and neck squamous cell carcinoma , young adult , retrospective cohort study , gastroenterology , oncology , head and neck cancer , radiation therapy , immunotherapy , cancer
Aim This study retrospectively investigated the efficacy and safety of nivolumab for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) classified using age <65 years as the cutoff. Methods Overall, 88 patients with R/M HNSCC treated with nivolumab were classified into the young group (<65 years; n = 39) and elderly group (≥65 years; n = 49). Efficacy was evaluated using overall survival (OS), progression‐free survival (PFS), overall response rate (ORR) and disease control rate (DCR). Safety was evaluated considering immune‐related adverse events (irAEs). Results The median OS was 9.7 and 8.6 months in the young and elderly groups, respectively. The 1‐year OS rate was 42.0% and 29.4% in the young and elderly groups, respectively. The median PFS was 3.0 and 4.2 months in the young and elderly groups, respectively. The 1‐year PFS rate was 30.0% and 27.9% in the young and elderly groups, respectively. In the young group, the ORR was 10.3% and DCR was 33.3%. In the elderly group, the ORR was 18.4% and DCR was 53.1%. There were no significant differences in OS, PFS, ORR, and DCR ( P = 0.36, 0.53, 0.29 and 0.06, respectively). Interstitial lung disease (ILD) as an irAE occurred in the young group at a significantly higher rate (20.5% vs 4.1%; P = 0.02). Conclusions There were no significant differences in OS, PFS, ORR, and DCR between the young and elderly groups. DCR tended to be better in the elderly group ( P = 0.06). ILD occurred at a significantly higher rate in the young group.