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Combined association of massive choroidal and optic nerve invasion as a prognostic relevance in primary retinoblastoma: A 10‐year study
Author(s) -
Kashyap Seema,
Singh Lata,
Kumar Nikhil,
Singh Mithalesh Kumar,
Pushker Neelam,
Bakhshi Sameer,
Sen Seema,
Lomi Neiwete,
Meel Rachna,
Chawla Bhavna
Publication year - 2021
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.13348
Subject(s) - retinoblastoma , optic nerve , medicine , proportional hazards model , ophthalmology , pathology , surgery , biology , biochemistry , gene
Purpose To determine the significance of both massive choroidal invasion and optic nerve invasion (retrolaminar [(RL]+cut end [CE]) as a criterion for classifying high metastatic potential retinoblastoma and their relationship with other known histopathological high‐risk features. Methods A retrospective review of 650 eyes diagnosed as retinoblastoma over a 10‐year period. In our study, there is male predominance and a higher percentage of the poorly differentiated tumors. The age of most of the patients ranges from 1 month to 8 years with a median age of 2 years. Results There were 24% of eyes with massive choroidal invasion and 18% of eyes with optic nerve invasion up to the cut end. On performing Cox‐proportional hazard analysis, it was found that massive choroidal invasion in association with optic nerve invasion up to the cut end was an independent prognostic parameter. On Kaplan‐Meier analysis, overall survival had reduced in patients having both massive choroidal invasion and an optic nerve cut end invasion along with orbital invasion ( P < .05). Conclusion The presence of massive choroidal invasion in association with optic nerve cut end invasion (RL+CE) could be used as a better prognostic predictor in assessing retinoblastoma patients with high metastatic potential and need to be kept for longer follow up.