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Management of patients with follicular lymphoma treated first line with obinutuzumab
Author(s) -
Opat Stephen,
Dickinson Michael,
Cheah Chan Yoon,
Tam Constantine,
Boulos Joy,
Thorburn Alison Nicole,
Trotman Judith
Publication year - 2019
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.13153
Subject(s) - obinutuzumab , follicular lymphoma , rituximab , medicine , oncology , reimbursement , lymphoma , adverse effect , intensive care medicine , health care , political science , law
Recently, obinutuzumab was included in the Australian Pharmaceutical Benefits Scheme for use in first line, advanced or bulky stage 2, follicular lymphoma, providing more immunochemotherapy treatment options available than ever before. Rituximab with chemotherapy has been the standard of care since reimbursement in the late 1990s; however, obinutuzumab‐based regimens have shown superior progression‐free survival in comparison to rituximab‐based options, albeit at an increased risk of grade ≥3 adverse events. As median overall survival approaches 20 years or more, the long‐term effects and sequencing of any strategy should be considered. Here we discuss the considerations for selection of front‐line therapy, based on evidence and local Australian clinician experience, in the management of first line follicular lymphoma.