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Association between human papillomavirus infection and prostate cancer: A global systematic review and meta‐analysis
Author(s) -
Moghoofei Mohsen,
Keshavarz Mohsen,
Ghorbani Saeed,
Babaei Farhad,
Nahand Javid Sadri,
Tavakoli Ahmad,
Mortazavi Helya Sadat,
Marjani Arezoo,
Mostafaei Shayan,
Monavari Seyed Hamidreza
Publication year - 2019
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.13124
Subject(s) - meta analysis , human papillomavirus , prostate cancer , association (psychology) , hpv infection , oncology , medicine , systematic review , cancer , virology , medline , cervical cancer , biology , psychology , biochemistry , psychotherapist
Abstract Although an increasing number of studies have been conducted to evaluate the association between human papillomavirus (HPV) infections and distribution of HPV types worldwide with the risk of prostate cancer (PC), the results remain inadequate. Hence, we investigated the association between HPV infection and PC risk using a meta‐analysis. Relevant studies from January 1990 to December 2016 were searched in PubMed, Web of sciences, and Scopus databases. Pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated to find the association between the prevalence of HPV and prostate cancer risk. To do so, data from 24 studies with 5546 prostate cancer cases were pooled in order to evaluate the heterogeneity of chief parameters including study region, specimen type, HPV DNA source, detection technique, publication calendar period, and Gleason score. All statistical analyses were performed using STATA 11 and MedCalc 13. A significant positive association was found between HPV infection and PC risk (OR = 1.281; P = 0.026). The genotype 16 was more frequently found in patients with PC which significantly increased the cancer risk (OR = 1.60; P < 0.001). Age 65 and older could significantly escalate PC risk (OR = 3.564; P < 0.001). Our results clearly favor the potential pathogenetic link between HPV infection and increased risk of PC affirming that HPV infections could play a part in the risk of PC.