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Hand–foot skin reaction predicts treatment outcome of pazopanib in patients with metastatic soft tissue sarcoma: A multicenter study in the Asian population
Author(s) -
Huang PeiWei,
Chou WenChi,
Shen WenChi,
Hung ChiaYen,
Huang KuanGen,
Su YuLi,
Lu ChangHsien,
Liu ChienTing,
Chang YuehShih,
Liau ChiTing
Publication year - 2018
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.13029
Subject(s) - pazopanib , medicine , soft tissue sarcoma , oncology , sarcoma , population , tyrosine kinase inhibitor , refractory (planetary science) , surgery , cancer , pathology , sunitinib , physics , environmental health , astrobiology
Aim Pazopanib is a multitargeted tyrosine kinase inhibitor used as a standard treatment for chemotherapy‐refractory recurrent or metastatic soft tissue sarcoma. This study aimed to evaluate the efficacy and safety of pazopanib for treatment of metastatic soft tissue sarcoma in the Asian population. Methods Fifty patients with chemotherapy‐refractory recurrent or metastatic soft tissue sarcoma, who had received pazopanib treatment between 2015 and 2016 were enrolled. We reviewed patients’ clinical characteristics and studied survival outcomes following pazopanib treatment. Results Median follow‐up was 5.7 months. Seven patients were still on pazopanib by the end of this study and the disease had progressed in the other 43 patients, leading to 23 deaths. We found that despite treatment more than half the patients experienced disease progression (56% vs 14% partial response and 30% stable disease). The median progression‐free survival and overall survival was 3.1 and 11.0 months, respectively. Multivariate analysis identified good Eastern Cooperative Oncology Group performance status (0 or 1) and occurrence of hand–foot skin reaction as independent factors associated with better outcome. Hand–foot skin reaction was 32% in our cohort and the median onset time was 4 (1.00–8.29) weeks. It had dose‐dependent effect by clinical observation. Conclusions Our study showed that the incidence rate of hand–foot skin reaction in Taiwan is higher than western population, and it is an independent predictive factor for better treatment outcomes.