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Cut‐point for Ki‐67 proliferation index as a prognostic marker for glioblastoma
Author(s) -
Wong Eugene,
Nahar Najmun,
Hau Eric,
Varikatt Winny,
Gebski Val,
Ng Thomas,
Jayamohan Jayasingham,
Sundaresan Puma
Publication year - 2019
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12826
Subject(s) - ki 67 , medicine , hazard ratio , confidence interval , proportional hazards model , proliferative index , survival analysis , log rank test , gastroenterology , proliferation index , pathology , immunohistochemistry
Ki‐67 proliferation index (Ki‐67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). Aim We aimed to assess correlation between Ki‐67 index and overall survival in patients with GB and determine a cut‐point for Ki‐67 index that predicts for poorer survival. Method Records of adult patients diagnosed with GB on histopathological specimens at a tertiary cancer center in Sydney between 1 January 2002 and 30 July 2012 were retrieved. Specimens of these patients were examined for quantification of Ki‐67 staining by two independent pathologists. Patient, disease, treatment, and survival data were collected from hospital and cancer care service records. Statistical analysis was performed using proportional hazards models, Kaplan–Meier curves, and the minimum P ‐value approach. Result Of the eligible 71 patients, 58% were males with median age of 58 (range 18–87). Seventy‐three percent of patients were of ECOG performance status 0–1. There was a statistically significant correlation between Ki‐67 index and overall survival. In patients with Ki‐67 > 22% ( n = 36), 5‐year survival was approximately 30% compared to 5% in those with Ki‐67 ≤ 22% ( n = 35; log‐rank P ‐value = 0.04; hazard ratio (HR) = 0.53; 95% confidence intervals (CI), 0.29–0.97). Conclusion This study demonstrates a positive correlation between Ki‐67 index and overall survival in patients with GB. Percentage staining of Ki‐67 < 22% appears to predict for poorer survival in GB.