Premium
Management of epidermal growth factor receptor tyrosine kinase inhibitor‐related cutaneous and gastrointestinal toxicities
Author(s) -
Aw Derrick ChenWee,
Tan Eng Huat,
Chin Tan Min,
Lim Hong Liang,
Lee Haur Yueh,
Soo Ross A.
Publication year - 2018
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12687
Subject(s) - erlotinib , medicine , gefitinib , afatinib , rash , epidermal growth factor receptor , adverse effect , paronychia , oncology , tyrosine kinase inhibitor , tyrosine kinase , cancer , dermatology , receptor
Patients with advanced stage non–small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations using EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib, gefitinib and afatinib as first‐line treatment had better progression‐free survival, overall response rate and quality of life than those on chemotherapy. Although EGFR TKIs are commonly associated with skin‐related (rash, xerosis and paronychia) and gastrointestinal‐related (diarrhea and stomatitis) adverse events (AEs), these effects are usually mild. But severe cases can occur, significantly affecting patient's well‐being, treatment compliance and quality of life. Therefore, patient education, early diagnosis, and prophylactic treatment are important strategies to optimally manage EGFR TKI‐related adverse effects. In this review, we summarize the commonly encountered EGFR TKI‐related AEs and provide a current overview of AE management in local practice with a focus on Asian patients.