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Differences in health‐related quality of life between European and Asian patients with hepatocellular carcinoma
Author(s) -
Chie WeiChu,
Blazeby Jane M,
Hsiao ChinFu,
Chiu HerngChia,
Poon Ronnie T,
Mikoshiba Naoko,
AlKadhim Gillian,
Heaton Nigel,
Calara Jozer,
Collins Peter,
Caddick Katharine,
Costantini Anna,
Vilgrain Valerie
Publication year - 2017
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12464
Subject(s) - hepatocellular carcinoma , medicine , quality of life (healthcare) , marital status , wilcoxon signed rank test , test (biology) , demography , environmental health , population , paleontology , nursing , sociology , biology , mann–whitney u test
Aim The aim of this study is to explore the possible effects of clinical and cultural characteristics of hepatocellular carcinoma on patients’ health‐related quality of life (HRQoL). Methods Patients with hepatocellular carcinoma from Asian and European countries completed the EORTC QLQ‐C30 and the EORTC QLQ‐HCC18. Comparisons were made using Student's t ‐test and Wilcoxon rank‐sum test with method of false discovery to correct multiple comparisons. Multiway analysis of variance and model selection were used to assess the effects of clinical characteristics and geographic areas. Results Two hundred and twenty‐seven patients with hepatocellular carcinoma completed questionnaires. After adjusting for demographic and clinical characteristics, Asian patients still had significantly better HRQoL scores in emotional functioning, insomnia, (QLQ‐C30) and in sexual interest (QLQ‐HCC18). We also found an interaction in physical functioning (QLQ‐C30) and fatigue (QLQ‐HCC18) between geographic region and marital status, married European had worse HRQoL scores than Asian singles. Conclusions Both clinical characteristics and geographic areas affected the HRQoL in with hepatocellular carcinoma. Cultural differences and clinical differences in the pattern of disease due to active surveillance of Asian countries may explain the results.