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Cognitive function in C hinese prostate cancer patients on androgen‐deprivation therapy: A cross‐sectional study
Author(s) -
Yang Jing,
Zhong Fei,
Qiu Ju,
Wang Kai
Publication year - 2015
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12347
Subject(s) - androgen deprivation therapy , prostate cancer , cross sectional study , medicine , oncology , cognition , cancer , gynecology , psychiatry , pathology
Aims Androgen‐deprivation therapy ( ADT ) is a main treatment option for patients with prostate cancer ( PCa ), but its effect on cognition remains unclear. The primary purpose of this cross‐sectional case‐control study was to evaluate the effects of ADT on cognition in Chinese PCa patients. Methods Participants included PCa patients who had undergone ADT ( ADT group, n = 33) and patients who did not undergo ADT (non‐ ADT group, n = 32), as well as age‐ and education‐matched healthy controls ( HC group, n = 35). All participants were examined using the neuropsychological battery aimed at assessing several cognitive domains including attention, memory and information processing performance. Results The ADT group obtained significantly worse scores than the non‐ ADT and HC groups in the following neuropsychological tests: Recognition ( P < 0.01), WAIS Digit Span forward ( P < 0.05), Trailmaking B ( P < 0.01) and Stroop Interference test ( P < 0.01). No significant difference was found between the non‐ ADT and HC groups ( P > 0.05). Conclusions Chinese PCa patients receiving ADT showed cognitive impairments in several domains including memory, attention and information processing performance.