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Prognostic factors and survival rate of osteosarcoma: A single‐institution study
Author(s) -
Faisham Wan Ismail,
Mat Saad Arman Zaharil,
Alsaigh Laith N,
Nor Azman Mat Z,
Kamarul Imran Musa,
Biswal Biswa M,
Bhavaraju Venkata MK,
Salzihan Md Salleh,
Hasnan Jaafar,
Ezane Aziz M,
Ariffin Nasir,
Norsarwany Mohamad,
Ziyadi Mohamad G,
Wan Azman Wan Sulaiman,
Halim Ahmad Sukari,
Zulmi Wan
Publication year - 2017
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12346
Subject(s) - medicine , osteosarcoma , chemotherapy , amputation , surgery , retrospective cohort study , survival rate , oncology , pathology
Abstract Aim Osteosarcoma is a highly malignant primary bone tumor. The study aim to evaluate the prognostic factors influencing the survival rate in our center. Methods This was a retrospective cohort study of all patients treated between J anuary 2005 and D ecember 2010. Results We included 163 patients with an age range of 6–59 years (median = 19). The median follow‐up was 47 months (range 36–84). The overall survival in patients who completed chemotherapy and surgery ( n = 117) was 72% at 2 years and 44% at 5 years. Histologically, 99 (85%) had osteoblastic, 6 (5%) had chondroblastic and 3 (2.5%) had telangiectatic osteosarcoma. Limb salvage surgery was performed in 80 (49%) and 41 (25%) underwent amputation. However, 46 patients (28%) underwent no surgical intervention and incomplete chemotherapy. In total, 38/79 patients had a good chemotherapy response. There was a significantly better survival rate for limb salvage versus amputation. Independent prognostic factors for survival are compliance to treatment and presence of lung metastasis. Conclusion The overall survival of osteosarcoma patients was influenced by the presence of pulmonary metastases and compliance to treatment. Histological subtype, different chemotherapy regimens and histological necrosis after chemotherapy did not significantly influence survival. The patients who did not complete treatment had significantly poorer survival.