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Comparison of external radiotherapy and percutaneous vertebroplasty for spinal metastasis
Author(s) -
Huang Min,
Zhu Hong,
Liu Taiguo,
Cui Dandan,
Huang Ying
Publication year - 2016
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12162
Subject(s) - medicine , percutaneous vertebroplasty , radiation therapy , metastasis , surgery , percutaneous , breast cancer , metastatic breast cancer , lung cancer , randomized controlled trial , neurological deficit , cancer , radiology , vertebral body
Aim To compare the efficacy of external radiotherapy ( ERT ) and percutaneous vertebroplasty ( PVP ) for spinal metastasis. Methods A total of 137 patients with 174 spinal metastases between J une 2006 and A pril 2009 in our hospital were reviewed. For their spinal metastasis, 52 patients received ERT ; 46 patients received PVP ; and 39 patients received both ERT and PVP . Pain and neurological deficit response, overall survival, and side effects were evaluated. Results ERT combined with PVP achieved pain remission in 84.8% of the patients, which was higher than ERT (72.5%) or PVP (76.3%) alone. It also showed a higher remission rate of neurological deficits (50%) than ERT (18.2%) or PVP (11.1%) alone. Toxicities from the employed treatments were mild. The K arnofsky Performance Score and visceral or brain metastases were the significant influencing factors for overall survival. Patients with spinal metastases derived from breast cancer had a significantly better overall survival than those whose spinal metastases were derived from lung cancer. Conclusion ERT combined with PVP can be a more effective treatment for spinal metastases; however, prospective randomized trials are needed to draw any definitive conclusion.