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Pretreatment maximum standardized uptake value on 18F ‐fluorodeoxyglucose positron emission tomography is a predictor of outcome for stage I non‐small cell lung cancer after stereotactic body radiotherapy
Author(s) -
Tanaka Hidekazu,
Hayashi Shinya,
Hoshi Hiroaki
Publication year - 2016
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12128
Subject(s) - medicine , standardized uptake value , nuclear medicine , positron emission tomography , lung cancer , fluorodeoxyglucose , stage (stratigraphy) , univariate analysis , radiosurgery , radiation therapy , metastasis , radiology , cancer , multivariate analysis , paleontology , biology
Aims Stereotactic body radiotherapy ( SBRT ) is commonly considered an important treatment option for patients with stage I non‐small cell lung cancer ( NSCLC ) who have contraindications for surgery or refuse surgery. Many studies have reported that the maximum standardized uptake value ( SUVmax ) on 18F ‐fluorodeoxyglucose positron emission tomography ( FDG‐PET ) of the primary tumor has prognostic value for resected NSCLC . The purpose of this study was to determine whether SUVmax is a predictor of disease‐free survival ( DFS ) in patients with stage I NSCLC after SBRT . Methods In all patients, the diagnosis was pathologically or cytologically confirmed. The prescription dose was 48 Gy in four fractions at the isocenter. FDG‐PET was performed before SBRT . Results Twenty‐nine patients were enrolled in this study. The median follow‐up period was 14 months (range, 2–56 months). Regional lymph node metastasis and distant metastasis were observed in 5 (17%) and 2 (7%), respectively. The median SUVmax was 5.6 (range, 2.2–22.0). DFS at 2 years was significantly different between the low SUVmax (<8.0) and high SUVmax (≥8.0) groups (85 versus 17%). In univariate analysis, SUVmax and gross tumor volume were significantly correlated with DFS . Multivariate analysis included variables with P ‐values <0.20 and showed that only SUVmax was significantly correlated with DFS . Conclusion Pretreatment SUVmax on FDG‐PET predicted the DFS in patients with stage I NSCLC after SBRT .