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Probiotics reduce psychological stress in patients before laryngeal cancer surgery
Author(s) -
Yang Hui,
Zhao Xiaoyun,
Tang Shan,
Huang Hua,
Zhao Xiulan,
Ning Zhuohui,
Fu Xiurong,
Zhang Caihong
Publication year - 2016
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12120
Subject(s) - medicine , anxiety , laryngectomy , placebo , cancer , malignancy , psychosocial , heart rate , depression (economics) , surgery , surgical stress , anesthesia , gastroenterology , larynx , blood pressure , psychiatry , pathology , alternative medicine , economics , macroeconomics
Aim Laryngeal cancer is a common malignancy; surgery is the preferred treatment. Psychosocial stress is one of the negative impacts on patient recovery. This study aimed to elucidate the effect of probiotics on ameliorating anxiety, and on serum corticotropin‐releasing factor ( CRF ) in laryngeal cancer patients before surgery. Methods A total 30 patients with laryngeal cancer and 20 healthy volunteers were recruited. During the 2 weeks before surgery, 20 patients were randomly allocated to receive probiotics or placebo twice a day. Heart rate was recorded daily. The degree of anxiety was assessed by the Hamilton Anxiety Scale ( HAMA ). Results Serum CRF levels in laryngeal cancer patients increased significantly in approaching surgery. After ingestion of probiotics, serum levels of CRF and heart rate did not increase before surgery. In addition, taking probiotics relieved the degree of anxiety of the patients from HAMA 19.8 to 10.2. Conclusion Probiotics can ameliorate the clinical anxiety and biochemical features of stress in patients scheduled for laryngectomy.