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Registry of gastric cancer treatment evaluation ( REGATE ): I baseline disease characteristics
Author(s) -
Bang YungJue,
Yalcin Suayib,
Roth Arnaud,
Hitier Simon,
TerOvanesov Mikhail,
Wu ChewWun,
Zalcberg John
Publication year - 2014
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12112
Subject(s) - medicine , cancer , disease , cancer registry , stage (stratigraphy) , paleontology , biology
Aims A better understanding of treatment patterns and outcomes in different countries should improve the management of patients with gastric cancer globally. The RE gistry of GA stric C ancer T reatment E valuation ( REGATE ) study was established to evaluate variations in gastric cancer disease characteristics and treatment patterns in different parts of the world. Methods REGATE was a prospective international registry enrolling patients with newly diagnosed gastric cancer at any stage of the disease. Results A total of 10 299 patients (65% male; mean age 59 years) were recruited in 22 countries between 2004 and 2008. Tumor location at a proximal site was more common in E urope, L atin A merica and N orth A frica (approximately 20%) than in A sia‐ P acific, where antral location predominated. Signet‐ring cell histology predominated except in E urope, where adenocarcinoma was most prevalent. Stage I cancers were more frequent in A sia‐ P acific (39%) versus other regions (6−18%), whereas stage IV cancers were more frequent outside A sia‐ P acific. Surgery was planned for most patients, although in general fewer patients actually received surgery than originally planned. Adjuvant therapy and palliative care were generally used more frequently than originally planned. Overall, 15% of patients received no treatment ( A sia‐ P acific 8%; Indian subcontinent 25%). Conclusions These results provide a comprehensive database representative of gastric cancer disease characteristics and treatment patterns across the world.