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A ssociation of plasma visfatin with risk of colorectal cancer: An observational study of C hinese patients
Author(s) -
Chen Mingwei,
Wang Youming,
Li Yongxiang,
Zhao Lili,
Ye Shuai,
Wang Shenyi,
Yu Changjun,
Xie Huijuan
Publication year - 2016
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12090
Subject(s) - medicine , odds ratio , colorectal cancer , confounding , case control study , waist , gastroenterology , biomarker , oncology , risk factor , cancer , receiver operating characteristic , body mass index , chemistry , biochemistry
Abstract Aim To investigate the association between plasma visfatin levels and risk of early and advanced colorectal cancer ( CRC ). Methods In total, 358 CRC patients and 286 controls were enrolled. According to the T factor of the TNM system. cancer patients were divided into two subgroups: early and advanced cancer. Levels of visfatin, anthropometric and metabolic parameters, which were classified as low, medium, and high, based on the tertile distributions in the control group, were determined. Results The visfatin levels in patients with advanced and early cancer were higher than in controls (least significant difference test, P = 0.004 and 0.013, respectively). The patients in the highest tertile of visfatin concentration presented significantly higher odds for early and advanced CRC , adjusted for potential confounding factors (odds ratio 3.37; 95% CI , 1.93–8.37; P = 0.011; odds ratio 2.38; 95% CI : 1.82–8.35; P = 0.015, respectively). The visfatin level correlated significantly with waist:hip ratio ( P < 0.05 for all) among case and control participants. Plasma visfatin levels in early and advanced CRC yielded a receiver operating characteristic curve area of 72 and 86%, respectively. The optimal sensitivity and specificity were 73% and 57% in discriminating between early CRC and normal controls while they were 76% and 68% in discriminating between advanced CRC and normal controls. Conclusion An increased level of visfatin was a strong risk factor for both early and advanced CRC in C hinese patients. Plasma visfatin levels might be a potential biomarker for CRC detection.