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Influence of ABO blood group and R hesus factor on breast cancer risk: A meta‐analysis of 9665 breast cancer patients and 244 768 controls
Author(s) -
Miao SuYu,
Zhou Wenbin,
Chen Ling,
Wang Shui,
Liu XiaoAn
Publication year - 2014
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12083
Subject(s) - breast cancer , abo blood group system , medicine , odds ratio , oncology , risk factor , blood type (non human) , cancer , meta analysis , population , confidence interval , case control study , gastroenterology , gynecology , environmental health
Aim Blood group is an important risk factor for some malignancies, including pancreatic and stomach cancer. However, it is unclear whether the risk of breast cancer is higher in any specific ABO blood type. Methods We searched the electronic database of P ub M ed, EMBASE , C hina N ational K nowledge I nfrastructure and the VIP C hinese J ournal of S cience and T echnology for case‐control studies about blood type and breast cancer incidence, and a meta‐analysis was conducted. Results Fourteen studies were eligible for assessment on the association of breast cancer with different blood types, including 9665 breast cancer patients and 244 768 controls. Relative to blood type O , women with blood type A (odds ratio ( OR ) = 1.115, 95% confidence interval ( CI ) 0.992–1.254), B ( OR = 0.983, 95% CI 0.915–1.056) and AB ( OR = 1.042, 95% CI 0.881–1.231) had the same breast cancer risk. The risk for women with R hesus‐positive ( R h+) was the same as those with R h‐negative ( R h‐) ( OR = 0.948, 95% CI 0.667–1.348). Among C aucasians, the OR of blood type A was 1.066 (95% CI , 1.001–1.134, P = 0.522 for heterogeneity). Conclusion This meta‐analysis suggests C aucasians with blood type A may have a higher risk of breast cancer than other Caucasians. No association was found in any other blood type or any other population. Similarly, the R h factor had no association with the risk of breast cancer.