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Role of octreotide in post chemotherapy and/or radiotherapy diarrhea: prophylaxis or therapy?
Author(s) -
Sun JuXian,
Yang Ning
Publication year - 2014
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12055
Subject(s) - octreotide , radiation therapy , medicine , diarrhea , chemotherapy , oncology , somatostatin
Aim The clinical efficacy of octreotide in controlling chemoradiotherapy‐induced diarrhea remains controversial. We conducted a meta‐analysis of randomized controlled trials ( RCT ) comparing octreotide with placebo in the prevention or therapy of chemoradiotherapy‐induced diarrhea. Methods A computerized literature search of M edline, EMBASE , C ochrane L ibrary and BIOSIS databases were performed for RCT comparing the use of octreotide versus placebo in the management of patients with chemoradiotherapy‐induced diarrhea. The main outcome measure was the response of the diarrhea. Results We included eight RCT comprising 572 patients. We found octreotide was significantly effective compared with the placebo ( OR , 4.9; 95%, 1.58–15.2).The overall effect of octreotide was 69% (204/294), while that of placebo was 54% (149/278). When divided into prophylactic and therapeutic subgroups, the prophylactic subgroup had an OR of 2.11 (95% CI , 0.51–2.89) for chemoradiotherapy‐induced diarrhea and the therapeutic subgroup had an OR of 7.30 (95% CI , 4.09–13.04). Conclusion In chemoradiotherapy‐induced diarrhea, octreotide is best used as a therapeutic rather than a prophylactic agent against diarrhea.