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Expression and significance of R ac1, P ak1 and R ock1 in gastric carcinoma
Author(s) -
Wu Yongjun,
Tang Yi,
Li Zhenfeng,
Li Zheng,
Zhao Yi,
Wu Zhenjiang,
Su Qi
Publication year - 2014
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/ajco.12052
Subject(s) - gastric carcinoma , chemistry , microbiology and biotechnology , biology , cancer research , cancer , medicine
Aims R ac1, P ak1 and R ock1 are indicators related to gastric cancer invasion and metastasis, but few reports discuss all three kinds of protein in research on gastric cancer invasion and metastasis. The aim of this study was to investigate the expression and clinical significance of R ac1, P ak1 and R ock1 in gastric carcinoma. Methods R ac1, P ak1 and R ock1 expression in 158 cases of gastric carcinoma were investigated via immunohistochemical staining and clinical analysis. Results The positive expression rates of R ac1, P ak1 and R ock1 in normal tissue, intraepithelial neoplastic tissues and gastric carcinoma showed an increasing trend ( P < 0.05). Their expression in lymph node metastasis was significantly higher than in patients with lymph‐node metastasis than in those without lymph nodes metastasis ( P < 0.05). Their expression in tumor ( TNM stages III and IV) were significantly higher than that in stages I and II ( P < 0.05). R ac1, P ak1 and R ock1 expression did not differ significantly with patients' sex ( P > 0.05). Conclusion Positive rates of R ac1, P ak1 and R ock1 expression in normal tissue, dysplasia and gastric carcinoma show an increasing trend and are correlated with tumor lymph node metastasis and TNM stage. R ac1, P ak1 and R ock1 may be important biomarkers of gastric carcinoma invasion and metastasis.