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Quetiapine adverse events in older adults in Australia
Author(s) -
ElSaifi Najwan,
Jones Cindy,
Moyle Wendy
Publication year - 2016
Publication title -
australasian journal on ageing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.63
H-Index - 34
eISSN - 1741-6612
pISSN - 1440-6381
DOI - 10.1111/ajag.12347
Subject(s) - older people , quetiapine , medicine , odds , odds ratio , adverse effect , psychiatry , logistic regression , gerontology , schizophrenia (object oriented programming)
Aim To characterise quetiapine reported adverse drug events ( ADE s) in older Australians in terms of type, frequency, severity and outcome, and to compare these characteristics with those of younger Australians. Methods Basic descriptive analyses were used to examine patient characteristics. The characteristics of reported ADE s were compared between older and younger Australians using odds ratios and chi‐squared tests. Results The most frequently reported ADE s in older people were nervous system disorders (23.7%). There were significantly more reports of skin and subcutaneous ADE s and hepatobiliary ADE s for older people than for younger people. More severe ADE s were reported in older people with death more likely to occur in older than in younger people Conclusion Significant differences between older and younger people in terms of reported ADE s, severity and mortality were found. There is a need for further prospective studies in older people on quetiapine to confirm the findings of this study.