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Case Series: Rapid Induction Onto Long Acting Buprenorphine Injection for High Potency Synthetic Opioid Users
Author(s) -
Mariani John J.,
Mahony Amy,
Iqbal Muhammad N.,
Luo Sean X.,
Naqvi Nasir H.,
Levin Frances R.
Publication year - 2020
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/ajad.13018
Subject(s) - buprenorphine , medicine , heroin , opioid use disorder , opioid , clonazepam , anesthesia , zolpidem , potency , pharmacology , drug , biochemistry , chemistry , receptor , in vitro , insomnia
Background and Objectives Highly potent synthetic opioids (HPSO) are increasingly responsible for opioid overdose deaths in the United States. Methods In an open‐label, uncontrolled trial to test the feasibility of extended‐release buprenorphine (BXR) injection treatment of heroin‐using individuals with opioid use disorder testing positive for HPSO, participants were enrolled and began an induction with sublingual BXR ( n = 5). During the induction, ancillary medications (clonidine, clonazepam, zolpidem, and prochlorperazine) were provided for breakthrough opioid withdrawal symptoms. Results Two participants received the BXR injection on the second day of the induction and three participants on the third day. Discussion and Conclusion All five participants were retained at least 1‐month postinduction. Scientific Significance It may be feasible to provide BXR treatment to HPSO‐positive heroin users rapidly to achieve clinical stabilization. (Am J Addict 2020;00:00–00)