Premium
Factors associated with willingness to participate in a pharmacologic addiction treatment clinical trial among people who use drugs
Author(s) -
Uhlmann Sasha,
Milloy Michael John,
Ahamad Keith,
Nguyen Paul,
Kerr Thomas,
Wood Evan,
Richardson Lindsey
Publication year - 2015
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/ajad.12200
Subject(s) - medicine , addiction , odds ratio , psychological intervention , methadone maintenance , confidence interval , logistic regression , heroin , odds , psychiatry , methadone , demography , drug , sociology
Background and Objectives Although new medications are needed to address the harms of drug addiction, rates of willingness to participate in addiction treatment trials among people who use drugs (PWUD), have not been well characterized. Methods One thousand twenty PWUD enrolled in two community‐recruited cohorts in Vancouver, Canada, were asked whether they would be willing to participate in a pharmacologic addiction treatment trial. Logistic regression was used to identify factors independently associated with a willingness to participate. Results Among the 1,020 PWUD surveyed between June 1, 2013 and November 30, 2013, 58.3% indicated a willingness to participate. In multivariate analysis, factors independently associated with a willingness to participate in a pharmacologic addiction treatment trial included: daily heroin injection (Adjusted Odds Ratio [AOR] = 1.75; 95% Confidence Interval [CI]: 1.13 – 2.72); daily crack smoking (AOR = 1.81; 95% CI: 1.23 – 2.66); sex work involvement (AOR = 2.22; 95% CI: 1.21 – 4.06); HIV seropositivity (AOR = 1.49; 95% CI: 1.15 – 1.94); and methadone maintenance therapy participation (AOR = 1.77; 95% CI: 1.37–2.30). Discussion and Conclusions High rates of willingness to participate in a pharmacologic addiction treatment trial were observed in this setting. Importantly, high‐risk drug and sexual activities were positively associated with a willingness to participate, which may suggest a desire for new treatment interventions among PWUD engaged in high‐risk behavior. Scientific Significance These results highlight the viability of studies seeking to enroll representative samples of PWUD engaged in high‐risk drug use. (Am J Addict 2014;XX:XX –XX).