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The role of genetics and epigenetics in the pathogenesis of gestational diabetes mellitus
Author(s) -
Rosik Jakub,
Szostak Bartosz,
Machaj Filip,
Pawlik Andrzej
Publication year - 2020
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12356
Subject(s) - epigenetics , gestational diabetes , genetics , glucokinase , hnf1a , biology , genome wide association study , disease , bioinformatics , diabetes mellitus , candidate gene , hepatocyte nuclear factors , pregnancy , medicine , single nucleotide polymorphism , endocrinology , gene , transcription factor , gestation , genotype
Abstract Diabetes mellitus (DM) is a heterogeneous group of disorders whose common trait is chronic hyperglycemia. Gestational diabetes mellitus (GDM) is one of the subtypes of DM that manifests during pregnancy. It is believed that 2%–5% of pregnancies worldwide are complicated with GDM, with the prevalence having significantly increased over the last decade. While the pathogenesis of the disease remains largely unknown, GDM is believed to be a result of interactions between genetic, epigenetic, and environmental factors. Linkage and association studies, including those that are genome‐wide, have allowed us to identify complex genetic and epigenetic mechanisms that lead to the development of GDM. Multiple common variants in candidate genes such as potassium inwardly rectifying channel subfamily J, member 11 (KCNJ11), glucokinase (GCK), or hepatocyte nuclear factor 1α (HNF1A) have been found to increase the disease risk. In this review, we provide a detailed overview of the current knowledge concerning the influence of genetics and epigenetics on the development of GDM.