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Association between TNF‐α polymorphisms and the risk of upper gastrointestinal bleeding induced by aspirin in patients with coronary heart disease
Author(s) -
Wang Taiping
Publication year - 2019
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12295
Subject(s) - aspirin , medicine , gastroenterology , odds ratio , genotyping , confidence interval , genotype , upper gastrointestinal bleeding , allele , haplotype , biology , gene , endoscopy , genetics
Objective To investigate the correlation of tumor necrosis factor α (TNF‐α) polymorphisms with upper gastrointestinal bleeding (UGIB) induced by enteric‐coated aspirin in coronary heart disease (CHD) patients. Methods In total, 154 CHD patients taking enteric‐coated aspirin were enrolled in this study. Patients were divided into the UGIB group ( n = 57) and non‐UGIB group ( n = 97) based on the presence or absence of signs of UGIB, respectively. TNF‐α polymorphism (‐857C > T, ‐863C > A, and ‐1031T > C) genotyping was performed using polymerase chain reaction (PCR) amplification with sequence‐specific primers (PCR‐SSP). Results Patients who had the CC genotype and C allele of ‐1031T > C exhibited a significantly increase risk of UGIB after receiving enteric‐coated aspirin (CC vs. TT: odds (OR) (95% confidence interval (CI)): 7.568 (1.527–37.49), P = 0.005; C vs. T: OR (95% CI): 1.852 (1.036–3.312), P = 0.036). Patients who had CA and CA + AA genotypes and the A allele of ‐863C > A also exhibited an increased risk of aspirin‐induced UGIB (CA vs. CC: OR (95% CI): 2.415 (1.143–5.101), P = 0.019: CA + AA vs. CC: OR (95% CI): 2.218 (1.123–4.381), P = 0.021; A vs. C: OR (95% CI): 1.788 (1.039–3.078), P = 0.035). However, the TNF‐α ‐857 C > T polymorphism was unrelated to the induction of UGIB by enteric‐coated aspirin in CHD patients ( P > 0.05). In addition, the haplotypes of CCC (‐1031T > C, ‐863C > A, and ‐857C > T) markedly reduced the risk of aspirin‐induced UGIB in CHD patients. Conclusion TNF‐α ‐863A and ‐1031C increased the risk of UGIB induction by enteric‐coated aspirin in CHD patients, whereas TNF‐α ‐857C > T was not correlated with the UGIB risk.