Premium
CRISPR‐Cas9: A cornerstone for the evolution of precision medicine
Author(s) -
Razzouk Sleiman
Publication year - 2018
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12271
Subject(s) - genome editing , crispr , cas9 , pace , genome , computational biology , personalized medicine , precision medicine , human genome , computer science , biology , genetics , gene , geodesy , geography
Modern genetic therapy incorporates genomic testing and genome editing. It is the finest approach for precision medicine. Genome editing is a state‐of‐the‐art technology to manipulate gene expression thus generating a particular genotype. It encompasses multiple programmable nuclease‐based approaches leading to genetic changes. Not surprisingly, this method triggered internationally a wide array of controversies in the scientific community and in the public since it transforms the human genome. Given its importance, the pace of this technology is exceptionally fast. In this report, we introduce one aspect of genome editing, the CRISPR/Cas9 system, highlight its potential to correct genetic mutations and explore its utility in clinical setting. Our goal is to enlighten health care providers about genome editing and incite them to take part of this vital debate.