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The Role of TLR4, TNF‐α and IL‐1β in Type 2 Diabetes Mellitus Development within a North Indian Population
Author(s) -
Doody Natalie E.,
Dowejko Monika M.,
Akam Elizabeth C.,
Cox Nick J.,
Bhatti Jasvinder S.,
Singh Puneetpal,
Mastana Sarabjit S.
Publication year - 2017
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12197
Subject(s) - type 2 diabetes mellitus , locus (genetics) , allele , diabetes mellitus , genetics , population , genotype , medicine , biology , endocrinology , gene , environmental health
Summary This study investigated the role of IL‐1β‐511 (rs16944), TLR4‐896 (rs4986790) and TNF‐α‐308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL‐1β‐511, TLR4‐896 and TNF‐α‐308 loci. The C allele of IL‐1β‐511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32–2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431–22.648]). In this study, we have demonstrated a conclusive association with IL‐1β‐511 locus and IL‐1β‐511‐TLR4‐896 diplotype (CC‐AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.