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Genetic Obesity Risk and Attenuation Effect of Physical Fitness in Mexican‐Mestizo Population: a Case‐Control Study
Author(s) -
CostaUrrutia Paula,
Abud Carolina,
FrancoTrecu Valentina,
Colistro Valentina,
RodríguezArellano Martha Eunice,
VázquezPérez Joel,
Granados Julio,
Seelaender Marilia
Publication year - 2017
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12190
Subject(s) - single nucleotide polymorphism , body mass index , waist , snp , obesity , population , medicine , demography , genetics , gerontology , biology , genotype , environmental health , gene , sociology
Summary We analyzed commonly reported European and Asian obesity‐related gene variants in a Mexican‐Mestizo population through each single nucleotide polymorphism (SNP) and a genetic risk score (GRS) based on 23 selected SNPs. Study subjects were physically active Mexican‐Mestizo adults ( n = 608) with body mass index (BMI) values from 18 to 55 kg/m 2 . For each SNP and for the GRS, logistic models were performed to test for simple SNP associations with BMI, fat mass percentage (FMP), waist circumference (WC), and the interaction with VO 2max and muscular endurance (ME). To further understand the SNP or GRS*physical fitness components, generalized linear models were performed. Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO 2max , and ME. ME attenuated the influence of APOB rs512535 and TNFA rs361525 on obesity risk in FMP. WC was significantly associated to GRS. Both ME and VO 2max attenuated GRS effect on WC. We report associations for 6 out of 23 SNPs and for the GRS, which confer obesity risk, a novel finding for Mexican‐Mestizo physically active population. Also, the importance of including physical fitness components variables in obesity genetic risk studies is highlighted, with special regard to intervention purposes.