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Association of rs11643718 SLC12A3 and rs741301 ELMO1 Variants with Diabetic Nephropathy in South Indian Population
Author(s) -
Bodhini Dhanasekaran,
Chidambaram Manickam,
Liju Samuel,
Revathi Balakannan,
Laasya Dhandapani,
Sathish Natarajan,
Kanthimathi Sekar,
Ghosh Saurabh,
Anjana Ranjit Mohan,
Mohan Viswanathan,
Radha Venkatesan
Publication year - 2016
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12174
Subject(s) - diabetic nephropathy , odds ratio , single nucleotide polymorphism , genotype , minor allele frequency , allele , medicine , nephropathy , body mass index , polymorphism (computer science) , genetic association , endocrinology , genetics , diabetes mellitus , biology , gastroenterology , gene
Summary This study reports on the association of genetic variants selected from previous genome‐wide association studies for type 2 diabetic nephropathy in south Indians. Eight variants were genotyped in 601 type 2 diabetic subjects without nephropathy (DM) and 583 type 2 diabetic subjects with nephropathy (DN) by MassARRAY. The minor allele frequencies of rs11643718 SLC12A3 variant and rs741301 ELMO1 variant were significantly different between DM and DN groups ( P = 0.029 and 0.016, respectively). A combined analysis showed that the subjects carrying the risk genotypes of both these variants (GG of rs11643718 + AG/AA of rs741301) had a significant association with DN with an odds ratio [adjusted for age, sex, Body Mass Index (BMI), HbA1c, and systolic Blood Pressure (BP)] of 1.73 (1.30–2.30, P = 1.72 × 10 –4 ) as compared to subjects carrying all other genotype combinations. This is the first study to report a significant association of the SLC12A3 rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.