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Hexokinase Domain Containing 1 ( HKDC1 ) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population
Author(s) -
Kanthimathi Sekar,
Liju Samuel,
Laasya Dhandapani,
Anjana Ranjit Mohan,
Mohan Viswanathan,
Radha Venkatesan
Publication year - 2016
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12155
Subject(s) - gestational diabetes , hexokinase , allele , genetic association , genetics , gene , biology , diabetes mellitus , population , genome wide association study , single nucleotide polymorphism , medicine , genotype , endocrinology , pregnancy , gestation , metabolism , glycolysis , environmental health
Summary Hexokinase domain containing 1 ( HKDC1 ), a novel human hexokinase gene, is known to affect glucose metabolism and was shown to have a strong association with 2‐h plasma glucose in pregnant women in a recent genome wide association study. This study aimed to evaluate the association of these regulatory variants of HKDC1 (rs1076224, rs4746822, rs2394529 and rs9645501) with gestational diabetes mellitus (GDM) in a South Indian population. The regulatory variants of HKDC1 were genotyped in unrelated 500 women with GDM and 510 non‐GDM individuals by using the MassARRAY system and by direct DNA sequencing. The minor alleles of the HKDC1 gene regulatory variants, namely rs10762264 and rs4746822, showed a significant association with GDM and these alleles conferred as much as 1.24 and 1.34 times higher risk for GDM, respectively. This is the first study to demonstrate the association of HKDC1 genetic variants with susceptibility to GDM.