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The Dopamine Receptor D2 ( DRD2 ) SNP rs1076560 is Associated with Opioid Addiction
Author(s) -
Clarke ToniKim,
Weiss Amy R. D.,
Ferarro Thomas N.,
Kampman Kyle M.,
Dackis Charles A.,
Pettinati Helen M.,
O'brien Charles P.,
Oslin David W.,
Lohoff Falk W.,
Berrettini Wade H.
Publication year - 2014
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/ahg.12046
Subject(s) - addiction , opioid , dopamine , single nucleotide polymorphism , dopamine receptor d2 , cocaine dependence , dopamine receptor , dopamine transporter , medicine , psychology , dopamine receptor d3 , psychiatry , pharmacology , genetics , gene , biology , receptor , dopaminergic , genotype
Summary The risk for drug addiction is partially heritable. Genes of the dopamine system are likely candidates to harbour risk variants, as dopamine neurotransmission is involved in mediating the rewarding effects of drugs of abuse. One functional single nucleotide polymorphism in dopamine receptor D2 ( DRD2 ), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre‐ and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (EA) ( n = 336) and African American (AA) ( n = 1034) cocaine addicts and EA ( n = 656) and AA ( n = 668) controls. We also analysed the role of rs1076560 in opioid dependence by genotyping EA ( n = 1041) and AA ( n = 284) opioid addicts. rs1076560 was found to be nominally associated with opioid dependence in EAs ( p = 0.02, OR = 1.27) and AAs ( p = 0.03, OR = 1.43). When both opioid‐addicted ancestral samples were combined, rs1076560 was significantly associated with increased risk for drug dependence ( p = 0.0038, OR = 1.29). This association remained significant after correction for multiple testing. No association was found with cocaine dependence. These data demonstrate the importance of dopamine gene variants in the risk for opioid dependence and highlight a functional polymorphism that warrants further study.