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GFRα‐1 is a reliable marker of bovine gonocytes/undifferentiated spermatogonia: A mini‐review
Author(s) -
Zhang XueMing
Publication year - 2021
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/ahe.12601
Subject(s) - gonocyte , glial cell line derived neurotrophic factor , biology , microbiology and biotechnology , neurotrophic factors , stem cell , receptor , genetics , endocrinology , sertoli cell , spermatogenesis
Identification of the specific biomarkers is of great importance to enrich and expand the gonocytes or spermatogonial stem cells (SSCs) in livestock. The glial cell line‐derived neurotrophic factor (GDNF) family receptor alpha‐1 (GFRα‐1) is a conserved marker of the gonocytes/SSCs in multiple species including rodents, primates and human; however, its expression in bovine gonocytes/SSCs is debated. Recently, we and other teams clearly demonstrated the expression of GFRα‐1 in bovine gonocytes/SSCs. This is useful for bovine gonocytes/SSCs‐related research or application. Nonetheless, new methods still need to be developed to identify the undifferentiated spermatogonial subsets in large livestock and elucidate their spermatogenic potency.