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Localization of amylin‐like immunoreactivity in the striped velvet gecko pancreas
Author(s) -
Suzuki H.,
Yamamoto T.
Publication year - 2018
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/ahe.12337
Subject(s) - amylin , pancreatic polypeptide , enteroendocrine cell , medicine , paracrine signalling , pancreas , endocrinology , pancreatic islets , delta cell , somatostatin , colocalization , biology , gastric chief cell , autocrine signalling , islet , microbiology and biotechnology , glucagon , hormone , endocrine system , insulin , receptor , stomach , gastric mucosa
Summary Immunohistochemical techniques were employed to investigate the distribution of amylin‐like immunoreactive cells in the pancreas of gecko Homopholis fasciata . Four types of endocrine cells were distinguished: insulin immunoreactive (B cells), pancreatic polypeptide immunoreactive ( PP cells), glucagon and pancreatic polypeptide immunoreactive (A/ PP cells) and somatostatin immunoreactive cells (D cells). Pancreatic islets contained B, A/ PP and D cells, whereas extrainsular regions contained B, D and PP cells. In the pancreatic islets, amylin‐like immunoreactive cells corresponded to B cells, but not to A/ PP or D cells. In the extrainsular regions, amylin‐like immunoreactive cells corresponded to either B or PP cells. Amylin secreted from intrainsular B cells may regulate pancreatic hormone secretion in an autocrine and/or a paracrine fashion. On the other hand, amylin secreted from extrainsular PP and B cells, and/or intrainsular B cells may participate in the modulation of calcium homoeostasis in an endocrine fashion.