z-logo
Premium
Distribution of Neurotensin and Somatostatin‐28 (1–12) in the Minipig Brainstem
Author(s) -
Sánchez M. L.,
Vecino E.,
Coveñas R.
Publication year - 2016
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/ahe.12194
Subject(s) - neurotensin , brainstem , nucleus , anatomy , neuropeptide , biology , chemistry , neuroscience , receptor , biochemistry
Summary Using an indirect immunoperoxidase technique, an in depth study has been carried out for the first time on the distribution of fibres and cell bodies containing neurotensin and somatostatin‐28 (1–12) ( SOM ) in the minipig brainstem. The animals used were not treated with colchicine. The distribution of neurotensin‐ and SOM ‐immunoreactive fibres was seen to be quite similar and was moderate in the minipig brainstem: a close anatomical relationship between both neuropeptides was observed. The distribution of cell bodies containing neurotensin or SOM was quite different and restricted. Cell bodies containing neurotensin were found in four brainstem nuclei: nucleus centralis raphae, nucleus dorsalis raphae, in the pars centralis of the nucleus tractus spinalis nervi trigemini and in the nucleus ventralis raphae. Cell bodies containing SOM were found in six nuclei/regions of the brainstem: nucleus ambiguus, nucleus dorsalis motorius nervi vagus, formatio reticularis, nucleus parabrachialis medialis, nucleus reticularis lateralis and nucleus ventralis raphae. According to the observed anatomical distribution of the immunoreactive structures containing neurotensin or SOM , the peptides could be involved in sleep‐waking, nociceptive, gustatory, motor, respiratory and autonomic mechanisms.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here