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Galanin is Co‐Expressed with Substance P, Calbindin and Corticotropin‐Releasing Factor ( CRF ) in The Enteric Nervous System of the Wild Boar ( Sus scrofa ) Small Intestine
Author(s) -
Czujkowska A.,
Arciszewski M. B.
Publication year - 2016
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/ahe.12179
Subject(s) - galanin , neuropeptide , medicine , endocrinology , biology , enteric nervous system , substance p , ileum , neuropeptide y receptor , small intestine , jejunum , receptor
Summary Galanin is a neuropeptide widely present in the enteric nervous system of numerous animal species and exhibiting neurotransmittery/neuromodulatory roles. Colocalization patterns of galanin with substance P ( SP ), corticotropin‐releasing factor ( CRF ) and calbindin were studied in the small intestine of the wild boar using immunofluorescence technique. We demonstrated the presence of SP in substantial populations of galanin‐immunoreactive ( IR ) submucous neurons. Additionally, different amounts of nerve fibres exhibiting simultaneous presence of galanin and SP were noted in the small intestinal smooth musculature, submucous ganglia, lamina muscularis mucosae and mucosa. In the wild boar duodenum, jejunum and ileum, the co‐expression of galanin and calbindin was limited to minor populations of submucous neurons only. Single galanin‐/ CRF ‐ IR nerve fibres were exclusively present in the duodenal and jejunal (but not ileal) mucosa. These results strongly suggest that galanin participates in neuronal control of the wild boar small intestine also by functional co‐operation with other biologically active neuropeptides.