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Mapping of Neurotensin in the A lpaca ( L ama pacos ) Brainstem
Author(s) -
Souza E.,
Aguilar L. A.,
DíazCabiale Z.,
Narváez J. A.,
Coveñas R.
Publication year - 2014
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/ahe.12067
Subject(s) - serotonergic cell groups , reticular formation , spinal trigeminal nucleus , brainstem , nucleus , anatomy , parabrachial nucleus , lateral reticular nucleus , superior colliculus , tegmentum , dorsal raphe nucleus , hypoglossal nucleus , pons , nucleus raphe magnus , medulla oblongata , inferior colliculus , periaqueductal gray , solitary tract , paramedian pontine reticular formation , midbrain , biology , neuroscience , central nervous system , nociception , biochemistry , receptor , serotonergic , serotonin
Summary We studied the distribution of cell bodies and fibres containing neurotensin (NT) in the brainstem of the alpaca using an indirect immunoperoxidase technique. Immunoreactive fibres were widely distributed throughout the brainstem, whereas the distribution of cell bodies was less widespread. Immunoreactive perikarya were only found in the mesencephalic and bulbar reticular formation, periaqueductal grey, nucleus of the solitary tract, laminar spinal trigeminal nucleus and in the inferior colliculus. A high density of fibres containing NT was found in the dorsal nucleus of the raphe, marginal nucleus of the brachium conjunctivum, locus coeruleus, inferior colliculus, inter‐peduncular nucleus, substantia nigra, periaqueductal grey, reticular formation of the mesencephalon, pons and medulla oblongata, nucleus of the solitary tract, laminar spinal trigeminal nucleus, hypoglossal nucleus, inferior central nucleus and in the tegmental reticular nucleus. The widespread distribution indicates that NT might be involved in multiple physiological actions in the alpaca brainstem; this must be investigated in the future as alpacas lives from 0 m above sea level to altitudes of up 5000 m and hence the involvement of this neuropeptide in special and unique regulatory physiological mechanisms could be suggested.