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InDels within caprine IGF 2 BP 1 intron 2 and the 3′‐untranslated regions are associated with goat growth traits
Author(s) -
Wang Z.,
Zhang X.,
Jiang E.,
Yan H.,
Zhu H.,
Chen H.,
Liu J.,
Qu L.,
Pan C.,
Lan X.
Publication year - 2020
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12871
Subject(s) - biology , indel , indel mutation , genetics , intron , fibroblast growth factor receptor , quantitative trait locus , untranslated region , gene , receptor , microbiology and biotechnology , fibroblast growth factor , single nucleotide polymorphism , messenger rna , genotype
Summary Insulin‐like growth factor 2 mRNA binding protein 1 ( IGF 2 BP 1) is involved in the Hedgehog pathway and has been shown to regulate the RNA stability of several growth‐related target genes. It is located in a quantitative trait locus showing a strong association with traits related to body size in ducks. Fibroblast growth factor receptor 1 ( FGFR 1) also participates in Hedgehog signaling pathways and has been reported to be associated with organic growth and development. FGFR 1 ‐knockout mice have been shown to have severe postnatal growth defects, including an approximately 50% reduction in body weight and bone mass. Meanwhile, nonsense‐mediated mRNA decay factor ( SMG 6) can maintain genomic stability, which is associated with organic growth and development. Therefore, we hypothesized that IGF 2 BP 1 , FGFR 1 and SMG 6 genes may play important roles in the growth traits of goats. In this study, the existence of two insertion/deletion (InDel) variants within IGF 2 BP 1 , one InDel within FGFR 1 and two InDels within SMG 6 was verified and their correlation with growth traits was analyzed in 2429 female Shaanbei white cashmere goats. Results showed both the 15 bp InDel in intron 2 and the 5 bp InDel in the 3′ regulatory region within IGF 2 BP 1 were significantly associated with growth traits ( P < 0.05) and goats with the combinatorial homozygous insertion genotypes of these two loci had the highest body weight ( P = 0.046). The other InDels within FGFR 1 and SMG 6 were not obviously associated with growth traits ( P > 0.05). Therefore, the two InDels in IGF 2 BP 1 were vital mutations affecting goat growth traits.