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Genome‐wide association studies for milk production traits in Valle del Belice sheep using repeated measures
Author(s) -
Sutera A. M.,
Riggio V.,
Mastrangelo S.,
Di Gerlando R.,
Sardina M. T.,
PongWong R.,
Tolone M.,
Portolano B.
Publication year - 2019
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12789
Subject(s) - genome wide association study , biology , genetic association , genetics , gene , snp , candidate gene , dairy cattle , heritability , milk production , single nucleotide polymorphism , zoology , microbiology and biotechnology , genotype
Summary Genome‐wide association studies ( GWAS es) have become a powerful tool for identifying genomic regions associated with important traits in livestock. Milk production traits in dairy sheep are measured at different time points during their life span. Using phenotypic data generated from longitudinal traits could improve the power of association studies but until now have received less attention in GWAS es as a methodology and has not been implemented. The aim of this study was to carry out a GWAS for milk production traits in Valle del Belice sheep using repeated measures. After quality control, 469 ewes and 37 228 SNP s were retained for the analysis, and phenotypic data included 5586 test‐day records for five milk production traits (milk yield, MY ; fat yield and percentage, FY and F%; protein yield and percentage, PY and P%). Nine SNP s located within or close to known genes were found to be associated with milk production traits. In particular, rs398340969, associated with both milk yield and protein yield, is located within the DCPS gene. In addition, rs425417915 and rs417079368, both associated with both fat percentage and protein percentage, are located within the TTC 7B gene and at 0.37 Mb within the SUCNR 1 gene respectively. In summary, the use of repeated records was beneficial for mapping genomic regions affecting milk production traits in the Valle del Belice sheep.