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Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens
Author(s) -
Ren T.,
Li W.,
Liu D.,
Liang K.,
Wang X.,
Li H.,
Jiang R.,
Tian Y.,
Kang X.,
Li Z.
Publication year - 2019
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12741
Subject(s) - biology , gene , genetics , genome , promoter , microbiology and biotechnology , gene expression
Summary Glutaminyl‐peptide cyclotransferase‐like ( QPCTL ) is an isoenzyme of glutaminyl‐peptide cyclotransferase ( QPCT ). QPCTL and QPCT catalyze the formation of N‐terminal modified pyroglutamate‐fractalkine and the chemokine CCL 2. The objective of this study was to investigate the association between insertions/deletions in the chicken QPCTL promoter region with growth traits in chickens. We first detected two insertion/deletion variants of QPCTL via whole‐genome resequencing analysis of DNA samples from Xichuan chickens. A total of 1896 individuals from 12 breeds were genotyped for 52‐ and 224‐bp insertions/deletions. We found two novel insertions/deletions in the promoter region of the chicken QPCTL gene and studied their association with chicken body weight and carcass traits. Our findings show that QPCTL can be a molecular marker for chicken genetics and breeding programs.