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Genome‐wide association analysis of residual feed intake in Junmu No. 1 White pigs
Author(s) -
Bai C.,
Pan Y.,
Wang D.,
Cai F.,
Yan S.,
Zhao Z.,
Sun B.
Publication year - 2017
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12609
Subject(s) - biology , white (mutation) , residual feed intake , genome wide association study , genetic association , genetics , zoology , residual , body weight , feed conversion ratio , genotype , gene , single nucleotide polymorphism , endocrinology , algorithm , computer science
Summary Residual feed intake ( RFI ) is a measure of feed efficiency. Pigs with low RFI have reduced feed costs without compromising their growth. For marker‐assisted selection, it is helpful to identify genes or genetic markers associated with RFI in animals with improved feed efficiency at an early age. Using Illumina's Porcine SNP 60 BeadChip, we performed a pilot genome‐wide association study of 217 Junmu No. 1 white male pigs phenotyped for RFI . Two‐step and one‐step methods were used separately to identify associated SNP s. Both methods obtained similar results. Twelve SNP s were identified as significantly associated with RFI at a Bonferroni adjusted P‐ level < 9.7 × 10 −7 , and 204 were found to have suggestive (moderately significant) association with RFI at P < 5 × 10 −5 . NMBR , KCTD 16, ASGR 1, PRKCQ , PITRM 1, TIAM 1 and RND 3 were identified as candidate genes for RFI .