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Haplotype structure and copy number polymorphism of the beta‐defensin 7 genes in diverse chicken breeds
Author(s) -
Lee M. O.,
Romanov M. N.,
Plemyashov K. V.,
Dementieva N. V.,
Mitrofanova O. V.,
Barkova O. Y.,
Womack J. E.
Publication year - 2017
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12552
Subject(s) - biology , haplotype , genetics , gene duplication , copy number variation , gene , linkage disequilibrium , allele , single nucleotide polymorphism , beta defensin , defensin , genome , genotype
Summary Beta‐defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta‐defensin 7 gene ( Av BD 7 ) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated Av BD 7 allele. We also found haplotypes upstream of the Av BD 6 regions that are strongly linked to the Av BD 7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the Av BD 6 gene, with two SNP s being flanking markers to detect duplication of the Av BD 7 .