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An atlas and analysis of bovine skeletal muscle long noncoding RNA s
Author(s) -
Liu X. F.,
Ding X. B.,
Li X.,
Jin C. F.,
Yue Y. W.,
Li G. P.,
Guo H.
Publication year - 2017
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12539
Subject(s) - rna , biology , non coding rna , messenger rna , rna editing , microbiology and biotechnology , gene expression , xist , skeletal muscle , computational biology , genetics , gene , anatomy , x inactivation , x chromosome
Summary Long noncoding RNA s (lnc RNA s) have various biological functions and have been extensively studied in recent years. However, the identification and characterization of bovine lnc RNA s in skeletal muscle has been very limited compared with that of lnc RNA s in other model organisms. In this study, 7188 bovine skeletal muscle lnc RNA s were identified by RNA ‐Seq and a stringent screening procedure in four different muscle tissues. These lnc RNA s shared many characteristics with other mammalian lnc RNA s, such as a shorter open reading frame and lower expression level than for mRNA s. Furthermore, the chromosomal locations and global expression patterns for these lnc RNA s are also described in detail. More importantly, we detected the important interaction relationships of lnc RNA s–mi RNA s– mRNA s related to muscle development among 36 lnc RNA s, 62 mi RNA s and 12 mRNA s. Our results provide a global expression pattern of lnc RNA s specific to bovine skeletal muscle and provide important targets for revealing the function of bovine muscle development by thoroughly studying the interaction relationships of lnc RNA s–mi RNA s– mRNA s.