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Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep
Author(s) -
Yuan Z.,
Liu E.,
Liu Z.,
Kijas J. W.,
Zhu C.,
Hu S.,
Ma X.,
Zhang L.,
Du L.,
Wang H.,
Wei C.
Publication year - 2017
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12477
Subject(s) - biology , candidate gene , gene , genetics , adaptability , snp , genotype , selection (genetic algorithm) , microbiology and biotechnology , single nucleotide polymorphism , ecology , artificial intelligence , computer science
Summary Fat‐tailed sheep have commercial value because consumers prefer high‐protein and low‐fat food and producers care about feed conversion rate. However, fat‐tailed sheep still have some scientific significance, as the fat tail is commonly regarded as a characteristic of environmental adaptability. Finding the candidate genes associated with fat tail formation is essential for breeding and conservation. To identify these candidate genes, we applied FST and hap FLK approaches in fat‐ and thin‐tailed sheep with available 50K SNP genotype data. These two methods found 6.24 Mb of overlapped regions and 43 genes that may associated with fat tail development. Gene annotation showed that HOXA 11 , BMP 2 , PPP 1 CC , SP 3 , SP 9 , WDR 92 , PROKR 1 and ETAA 1 may play important roles in fat tail formation. These findings provide insight into tail fat development and a guide for molecular breeding and conservation.