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Genome‐wide association study for the level of serum electrolytes in Italian Large White pigs
Author(s) -
Bovo S.,
Schiavo G.,
Mazzoni G.,
Dall'Olio S.,
Galimberti G.,
Calò D. G.,
Scotti E.,
Bertolini F.,
Buttazzoni L.,
Samorè A. B.,
Fontanesi L.
Publication year - 2016
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12459
Subject(s) - genome wide association study , single nucleotide polymorphism , snp , biology , genetic association , genetics , gene , genotype
Summary Calcium, magnesium and phosphorus are essential electrolytes involved in a large number of biological processes. Imbalance of these minerals in blood may indicate clinically relevant conditions and are important in inferring acute or chronic pathologies in humans and animals. In this work, we carried out a genome‐wide association study ( GWAS ) for the level of these three electrolytes in the serum of 843 performance‐tested Italian Large White pigs. All pigs were genotyped with the Illumina Porcine SNP 60 BeadChip, and GWAS was carried out using genome‐wide efficient mixed‐model association. For the level of Ca 2+ , eight single nucleotide polymorphisms ( SNP s) were significant, considering a false discovery rate ( FDR ) < 0.05, and another eight were above the moderate association threshold ( P nominal value < 5.00E‐05). These SNP s are distributed in four porcine chromosomes ( SSC ): SSC 8, SSC 11, SSC 12 and SSC 13. In particular, a few putative different signals of association detected on SSC 13 and one on SSC 12 were in genes or close to genes involved in calcium metabolism ( P2 RY 1 , RAP 2B, SLC 9A9, C3orf58 , TSC 22D2, PLCH 1 and CACNB 1 ). Only one SNP (on SSC 7) and six SNP s (on SSC 2 and SSC 7) showed moderate association with the level of magnesium and phosphorus respectively. The association signals for these two latter minerals might identify genes not known thus far for playing a role in their biological functions and regulations. In conclusion, our GWAS contributed to increased knowledge on the role that calcium, magnesium and phosphorus may play in the genetically determined physiological mechanisms affecting the natural variability of mineral levels in mammalian blood.