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SNP genotypes of olfactory receptor genes associated with olfactory ability in German Shepherd dogs
Author(s) -
Yang M.,
Geng G.J.,
Zhang W.,
Cui L.,
Zhang H.X.,
Zheng J.L.
Publication year - 2016
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12389
Subject(s) - genotype , biology , snp , odor , genetics , olfactory receptor , polymorphism (computer science) , gene , single nucleotide polymorphism , receptor , neuroscience
Summary To find out the relationship between SNP genotypes of canine olfactory receptor genes and olfactory ability, 28 males and 20 females from German Shepherd dogs in police service were scored by odor detection tests and analyzed using the Beckman GenomeLab SNP stream. The representative 22 SNP loci from the exonic regions of 12 olfactory receptor genes were investigated, and three kinds of odor (human, ice drug and trinitrotoluene) were detected. The results showed that the SNP genotypes at the OR 10H1‐like: c.632C>T, OR 10H1‐like: c.770A>T, OR 2K2‐like: c.518G>A, OR 4C11‐like: c.511T>G and OR 4C11‐like: c.692G>A loci had a statistically significant effect on the scenting abilities ( P < 0.001). The kind of odor influenced the performances of the dogs ( P < 0.001). In addition, there were interactions between genotype and the kind of odor at the following loci: OR 10H1‐like: c.632C>T, OR 10H1‐like: c.770A>T, OR 4C11‐like: c.511T>G and OR 4C11‐like: c.692G>A (P < 0.001). The dogs with genotype CC at the OR 10H1‐like: c.632C>T, genotype AA at the OR 10H1‐like: c.770A>T, genotype TT at the OR 4C11‐like: c.511T>G and genotype GG at the OR 4C11‐like: c.692G>A loci did better at detecting the ice drug. We concluded that there was linkage between certain SNP genotypes and the olfactory ability of dogs and that SNP genotypes might be useful in determining dogs' scenting potential.