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PEG 3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses
Author(s) -
Li Shun,
Pausch Hubert,
Venhoranta Heli,
Adamowicz Krzysztof,
Andersson Magnus,
Zwierzchowski Lech,
Kind Alexander,
Schnieke Angelika,
Flisikowski Krzysztof
Publication year - 2016
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12373
Subject(s) - placenta , biology , genomic imprinting , cpg site , methylation , dna methylation , gene , gene expression , andrology , intrauterine growth restriction , genetics , microbiology and biotechnology , fetus , pregnancy , medicine
Summary We used a genetic ( MIMT 1 Del ) model of intrauterine growth restriction to investigate dysregulation of PEG 3 domain gene expression in bovine foetal and maternal placenta. ZIM 2 , APEG 3 and PEG 3 expressions were similarly reduced in MIMT 1 Del/WT foetal placenta, suggesting coordinated regulation. Methylation of DNA CpG sites associated with these genes showed no differences, but differences in the levels of MIMT 1 RNA methylation at three CpG sites were found in foetal placenta. Our data are consistent with the presence of a bidirectional promoter 5′ of MIMT 1 and suggest a regulatory role for the MIMT 1 non‐coding transcript. PEG 3 domain expression on the maternal placenta side was not affected by the foetal mutation.