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Genome‐wide association study of growth traits in Jinghai Yellow chicken hens using SLAF‐seq technology
Author(s) -
Wang W. H.,
Wang J. Y.,
Zhang T.,
Wang Y.,
Zhang Y.,
Han K.
Publication year - 2019
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12346
Subject(s) - biology , single nucleotide polymorphism , genome wide association study , snp , genetics , locus (genetics) , quantitative trait locus , bonferroni correction , genetic association , genome , trait , gene , genotype , statistics , mathematics , computer science , programming language
Summary In this study, we performed a new genome‐wide association study using SLAF‐seq technology. A total of 19 single nucleotide polymorphism effects involving nine different SNP markers reached 5% Bonferroni‐corrected genome‐wide significance. In addition, a 5‐Mb region spanning 72.9–77.9 Mb on GGA4, exhibiting many significant SNP effects, was identified. The LDB2 gene in this region had a very strong association with body weight. Another SNP on GGA1, located in the INTS6 gene, had the strongest association with late body weight (weeks 10–16). Some of the SNPs that reached suggestive significance level overlapped with previously reported quantitative trait locus regions.