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Genome‐scale identification of mi RNA – mRNA and mi RNA –lnc RNA interactions in domestic animals
Author(s) -
Li A.,
Zhang J.,
Zhou Z.,
Wang L.,
Sun X.,
Liu Y.
Publication year - 2015
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/age.12329
Subject(s) - biology , microrna , messenger rna , rna , genetics , computational biology , gene
Summary Domestic animals show considerable genetic diversity. Previous studies suggested that animal phenotypes were affected by mi RNA – mRNA interplay, but these studies focused mainly on the analysis of one or several mi RNA – mRNA interactions. However, in this study, we investigated mi RNA – mRNA and mi RNA –lnc RNA interactions on a genomic scale using miranda and targetscan algorithms. There has been strong directional artificial selection practiced during the domestication of animals. Thus, we investigated SNP s that were located in mi RNA s and mi RNA binding sites and found that several SNP s located in 3′‐ UTR s of mRNA s had the potential to affect mi RNA – mRNA interactions. In addition, a database, named mi RB ond, was developed to provide visualization, analysis and downloading of the resulting datasets. Our results open the way to further experimental verification of mi RNA – mRNA and mi RNA –lnc RNA interactions as well as the influence of SNP s upon such interplay.